Endocrine Abstracts

Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits insulin secretion, but GLP-1 increases insulin secretion in spite of stimulating somatostatin secretion from δ-cell. So, we investigated whether there exists a time difference of insulin and somatostatin secretion inside the islets after GLP-1 stimulation or insulin secretion depends on secreted GLP-1 or somatostatin conce...